Background/Objectives: Novel mRNA vaccines have been successfully utilized to curtail the SARS-CoV-2 pandemic.However, the immunology underlying CoV2 vaccinations, particularly with repeated boosting, has not been properly characterized due to limitations in the preclinical modeling of SARS-CoV-2 infection/vaccinations as well as constantly changin
A Novel Method for Survival Prediction of Hepatocellular Carcinoma Using Feature-Selection Techniques
The World Health Organization (WHO) predicted that 10 million people would have died of cancer by 2020.According to recent studies, liver cancer is the most prevalent cancer worldwide.Hepatocellular carcinoma (HCC) is the leading cause of early-stage liver cancer.However, Inlet Valve Connector HCC occurs most frequently in patients with chronic liv
Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders
Heme oxygenase-1 (HO-1) is an inducible stress protein that Firewire catalyzes the oxidative conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is converted to bilirubin (BR) by biliverdin reductase.HO-1 has been implicated as a cytoprotectant in various models of acute organ injury and disease (i.e., lung, k
A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat
ABSTRACT Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2.The innate immune systems of these immensely abundant, anciently diverged mammals rema